Multimodal Nanomaterials for Biomedicine

by Prof. Dr. Stefan Jurga

09.11.2017, 17:00 h, TF, Aquarium

Although still in its infancy, the field of multimodal nanomaterials has shown great potential in emerging biomedical fields such as imaging (optical, MRI), theranostics (therapy and diagnosis), including drug and gene delivery. The development of theranostic nanoplatforms for simultaneous therapy and diagnosis particularly in cancer treatment is enabled by the use of multifunctional nanomaterials or combination of nanomaterials with different functionalities. In this talk, I will summarize several types of multi-functional nanomaterials, based on carbon nanomaterials [1], quantum dots [2,3], nanoparticles containing rare earth elements [4], magnetic iron oxide nanoparticles [5,6], and metallic nanoparticles [7-8]. Special attention will be paid to application of multifunctional magnetic nanoplatform in gene therapy of glioblastoma multiform. We demonstrate the application of magnetic nanoparticles coated with polyethylenimine for nano-mediated RNAi therapy of glioblastoma by downregulating Tenascin-C (TN-C). The obtained nanomaterials were characterized by FTIR,TEM,SQUID and Zeta-potential. The broad spectrum of test including WST, SRB, LIVE/DEAD assays were performed to evaluate the cytotoxicity of nanocomposites. Their efficiency in downregulation of TN-C was assessed by means of RT-PCR and internalization of nanocomposites was checked by confocal microscopy. Moreover, contrast properties of nanomaterial were investigated by MRI. In conclusion, our results indicate that synthesized nanoplatform can serve as theranostic tool for glioblastoma treatment.

References

[1] Baranowska-Korczyc A. et al. PEG–MWCNT/Fe hybrids as multi-modal contrast agents for MRI and optical imaging, RSC Adv 2016 (55) 49891-49902.

[2] Michalska M. et al. Peptide-functionalized ZCIS QDs as fluorescent nanoprobe for targeted HER2-positive breast cancer cells imaging, Acta Biomater 2016 (35) 293-304.

[3] Przysiecka Ł. et al., iRGD peptide as effective transporter of CuInZnxS2+x quantum dots into human cancer cells, Colloids Surf B Biointerfaces 146 (2016) 9-18.

[4] N. Babayevska et al. Functionalized multimodal ZnO@Gd2O3 nanosystems to use as perspective contrast agent for MRI, Appl Surf Sci 2017 (404) 129-137.

[5] Grześkowiak B.F. et al. Nanomagnetic activation as a way to control the efficacy of nucelic acid delivery, Pharm Res 2015 (32) 103-121.

[6] Mrówczyński R. et al. Assessment of polydopamine coated magnetic nanoparticles in doxorubicin delivery, RSC Adv 2016 (6) 5936-5943.

[7] Woźniak-Budych M. et al. Green synthesis of rifampicin-loaded copper nanoparticles with enhanced antimicrobial activity , J Mater Sci: Mater Med 2017 (28) 42-45.

[8] Woźniak A. et al. Cytotoxicity and imaging studies of β-NaGdF4:Yb3+Er3+@ PEG-Mo nanorods, RSC Adv 2016 (6) 95633-95643.

Contact

sfb1261@tf.uni-kiel.de

Chairman:

Prof. Dr. Eckhard Quandt

Kiel University
Institute for Materials Science

 

Interner Server

 

CAU

Christian-Albrechts-Universität zu Kiel (CAU)

Christ.-Albrechts-Platz 4
D-24118 Kiel

UKSH

University Hospital Schleswig-Holstein, Campus Kiel (UKSH)

Arnold-Heller-Straße 3
D-24105 Kiel

ISIT

Fraunhofer Institute for Silicon Technology, Itzehoe (ISIT)

Fraunhoferstrasse 1
D-25524 Itzehoe  

IPN

IPN - Leibniz-Institut für die Pädagogik der Naturwissenschaften und Mathematik an der Universität Kiel

Olshausenstraße 62 
D-24118 Kiel

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