Computational Studies on the Volume of Activated Tissue in Deep Brain Stimulation

by Prof. Dr. rer. nat. habil. Ursula van Rienen, Lehrstuhl Theoretische Elektrotechnik, Universität Rostock

06.09.2018, 17:00 h, TF, Aquarium


Deep Brain Stimulation (DBS) is a widely used neuronal stimulation therapy for movement disorders like Parkinson’s disease and dystonias. Simulation studies can help for a deeper understanding of this therapy and, in future, for a patient-specific therapy planning aiming to prevent side effects as well. On the other hand, simulations can help e.g. to optimally select stimulation parameters in animal models.

The dielectric properties of biological tissue are based on experimental data and are subject to uncertainty, which arises from difficulties associated with the measuring process such as electrode polarisation at low frequencies, changes in the conditions of the tissue samples post mortem, and inter-individual variations. Based on the current state of measurement techniques for the dielectric properties of biological tissue, it can be assumed that uncertainty in these measurements and the resulting tissue properties will be a non-negligible factor, which has to be considered in computational models of bio-electrical applications.

In this contribution, we will introduce to the simulation pipeline to compute the Volume of Tissue Activated for a human model including uncertainty quantification and show some exemplary simulation results.



Prof. Dr. Eckhard Quandt

Kiel University
Institute for Materials Science


Internal server



Christian-Albrechts-Universität zu Kiel (CAU)

Christ.-Albrechts-Platz 4
D-24118 Kiel


University Hospital Schleswig-Holstein, Campus Kiel (UKSH)

Arnold-Heller-Straße 3
D-24105 Kiel


Fraunhofer Institute for Silicon Technology, Itzehoe (ISIT)

Fraunhoferstrasse 1
D-25524 Itzehoe  


IPN - Leibniz-Institut für die Pädagogik der Naturwissenschaften und Mathematik 

Olshausenstraße 62 
D-24118 Kiel

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